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Table 3 Comparison of device categories

From: Devices used for photobiomodulation of the brain—a comprehensive and systematic review

Device category

Design

Advantages

Disadvantages

Most commonly used

Laser handpiece

Control unit and a fibre optic cable that connects to the handpiece

Versatile; easy to handle; quickly placed; simple construction; precise treatment

Operator dependent

Model CG-5000 laser

LED cluster

Control unit and LED cluster (usually flat) with higher number of LED diodes, or a single component containing the LEDs and control unit

Wide actuation area; solutions to fix the device; multiple simultaneous placements

No precise treatment

MedX health model 1100

LED helmet

LED clusters arranged in a helmet shape; LEDs incrusted in a metal or plastic structure; or neoprene pads filled with LED rows

Straightforward placement; home use; autonomy; simultaneous stimulation of different areas

May not fit different head sizes; higher power—requires cooling systems

Cognitolite transcranial photomodulation system and the thor photomedicine LED lined helmet

Laser helmet

LEDs incrusted in plastic structure, shaped like a helmet

Straightforward placement; home use; autonomy; simultaneous stimulation of different areas

May not fit different head sizes; higher power—requires cooling systems

Localized LED helmet

Two metallic straps placed on the top and crown of the head, with three posterior transcranial LEDS, one anterior transcranial LED, and one intranasal LED

Home use; simple positioning; light weight; with intranasal

Specific locations of the LEDs—can limit use for certain health conditions

Vielight® Neuro Gamma and Vielight Neuro Alfa

LED headband

Headband with sensors and LEDs and a plastic cover to disguise the mechanical components. Connected to a portable control unit

Wide actuation area; home use; portable

More suited for forehead; NIRS device

OEG-SpO2 and Cerebral Science

Laser needles

Four stainless steel laser needles connected to a control unit through fibre optics. Held in place with wire holders attached to a crown

Fixation system; may allow simultaneous stimulation of different locations

Time consuming; complex fixation system; small actuation area

Laser WeberMedical Klasse 1, type BF, laser class 3B

Intranasal LED

Single LED with control unit

Simple; light weight; portable; stimulation of interior brain

More invasive, more structures to penetrate

Vielight® intranasal 810

Intranasal laser

Single laser with control unit

Simple; light weight; portable; stimulation of interior brain

More invasive, more structures to pass through

BLOODCARE medical laser device