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Table 1 Statistical non-inferiority (equivalence) test results for comparisons made between Control and Dual-RPNI study groups using percent EMG activity calculated from 32 strides

From: Adjacent regenerative peripheral nerve interfaces produce phase-antagonist signals during voluntary walking in rats

  Phase Study group Mean S D. 20% Window 95% C.I. Non-inferior?  
    (μ) (s) [θ L ,θ U ] [c L ,c U ] [c L ,c U ][θ L ,θ U ]  
Tibial n. Stance Control 65.77 13 66 [-13.16, 13.16] [ -4.49, 6.73 ] Yes
   Dual-RPNI 66.89 8 68    
  Swing Control 34.22 13 61 [ -6.84, 6.84 ] [ -6.70, 4.47 ] Yes
   Dual-RPNI 33.11 8 64    
Peroneal n. Stance Control 25.41 7 98 [-5.08, 5.08] [4.42, 13.19] Noa
   Dual-RPNI 34.20 9 82    
  Swing Control 74.58 7 96 [-14.91, 14.91] [-13.17, -4.43] Yes
   Dual-RPNI 65.78 9 79    
  1. Comparisons between groups were made between signals acquired from similarly-innervated muscle as a function of gait phase. The 20% Window was calculated around each control mean. The 95% C.I. was calculated using Eq. 1. Statistical equivalence between respective Dual-RPNI and Control percent EMG activity is inferred with (p<0.05) if the 95% C.I. is completely contained within the 20% Window
  2. aThe non-inferiority criterion for Dual-RPNI percent EMG activity calculated from the peroneal innervated muscle graft during stance is met if the low signals acquired from the last seven gaits of the Control group peroneal nerve activity during stance (see Fig. 4 b) are considered outliers
  3. Abbreviations: N nerve, SD standard deviation, CI confidence interval