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Table 1 Statistical non-inferiority (equivalence) test results for comparisons made between Control and Dual-RPNI study groups using percent EMG activity calculated from 32 strides

From: Adjacent regenerative peripheral nerve interfaces produce phase-antagonist signals during voluntary walking in rats

 

Phase

Study group

Mean

S D.

20% Window

95% C.I.

Non-inferior?

 
   

(μ)

(s)

[θ L ,θ U ]

[c L ,c U ]

[c L ,c U ]⊂[θ L ,θ U ]

 

Tibial n.

Stance

Control

65.77

13

66

[-13.16, 13.16]

[ -4.49, 6.73 ]

Yes

  

Dual-RPNI

66.89

8

68

   
 

Swing

Control

34.22

13

61

[ -6.84, 6.84 ]

[ -6.70, 4.47 ]

Yes

  

Dual-RPNI

33.11

8

64

   

Peroneal n.

Stance

Control

25.41

7

98

[-5.08, 5.08]

[4.42, 13.19]

Noa

  

Dual-RPNI

34.20

9

82

   
 

Swing

Control

74.58

7

96

[-14.91, 14.91]

[-13.17, -4.43]

Yes

  

Dual-RPNI

65.78

9

79

   
  1. Comparisons between groups were made between signals acquired from similarly-innervated muscle as a function of gait phase. The 20% Window was calculated around each control mean. The 95% C.I. was calculated using Eq. 1. Statistical equivalence between respective Dual-RPNI and Control percent EMG activity is inferred with (p<0.05) if the 95% C.I. is completely contained within the 20% Window
  2. aThe non-inferiority criterion for Dual-RPNI percent EMG activity calculated from the peroneal innervated muscle graft during stance is met if the low signals acquired from the last seven gaits of the Control group peroneal nerve activity during stance (see Fig. 4 b) are considered outliers
  3. Abbreviations: N nerve, SD standard deviation, CI confidence interval