Personalized modeling workflow for massive skeletal reconstruction, as developed by the Medical Technology Laboratory at the Rizzoli Orthopedic Institute in Bologna, Italy. a) CT scan of the lower limbs performed at follow-up, with motion capture markers visible as well. b) Focused view of reconstructed femur immediately after surgery. c) Patient-specific musculoskeletal model superimposed on CT images (LHPBuilder, B3C, Italy). d) One frame of dynamic walking simulation performed with the patient-specific model (OpenSim). Image courtesy of Dr. Giordano Valente, Rizzoli Orthopedic Institute, Bologna, Italy.