- Open Access
Quantifying kinematics of purposeful movements to real, imagined, or absent functional objects: Implications for modelling trajectories for robot-assisted ADL tasks**
© Wisneski and Johnson; licensee BioMed Central Ltd. 2007
- Received: 14 May 2006
- Accepted: 23 March 2007
- Published: 23 March 2007
Robotic therapy is at the forefront of stroke rehabilitation. The Activities of Daily Living Exercise Robot (ADLER) was developed to improve carryover of gains after training by combining the benefits of Activities of Daily Living (ADL) training (motivation and functional task practice with real objects), with the benefits of robot mediated therapy (repeatability and reliability). In combining these two therapy techniques, we seek to develop a new model for trajectory generation that will support functional movements to real objects during robot training. We studied natural movements to real objects and report on how initial reaching movements are affected by real objects and how these movements deviate from the straight line paths predicted by the minimum jerk model, typically used to generate trajectories in robot training environments. We highlight key issues that to be considered in modelling natural trajectories.
Movement data was collected as eight normal subjects completed ADLs such as drinking and eating. Three conditions were considered: object absent, imagined, and present. This data was compared to predicted trajectories generated from implementing the minimum jerk model. The deviations in both the plane of the table (XY) and the saggital plane of torso (XZ) were examined for both reaches to a cup and to a spoon. Velocity profiles and curvature were also quantified for all trajectories.
We hypothesized that movements performed with functional task constraints and objects would deviate from the minimum jerk trajectory model more than those performed under imaginary or object absent conditions. Trajectory deviations from the predicted minimum jerk model for these reaches were shown to depend on three variables: object presence, object orientation, and plane of movement. When subjects completed the cup reach their movements were more curved than for the spoon reach. The object present condition for the cup reach showed more curvature than in the object imagined and absent conditions. Curvature in the XZ plane of movement was greater than curvature in the XY plane for all movements.
The implemented minimum jerk trajectory model was not adequate for generating functional trajectories for these ADLs. The deviations caused by object affordance and functional task constraints must be accounted for in order to allow subjects to perform functional task training in robotic therapy environments. The major differences that we have highlighted include trajectory dependence on: object presence, object orientation, and the plane of movement. With the ability to practice ADLs on the ADLER environment we hope to provide patients with a therapy paradigm that will produce optimal results and recovery.
- Stroke Survivor
- Functional Task
- Functional Movement
- Table Constraint
- Movement Smoothness
Stroke is a major cause of adult disability in the United States with over 5 million people living in the US with post stroke effects. Often stroke survivors are left with severe disability and hemiparesis that makes functioning in their daily living environment extremely challenging or impossible without complete assistance. There is a need for improved methods of rehabilitation and an increase in the rehabilitation efforts made [1, 2].
The question of what is the best approach to stroke therapy is currently a topic for much debate [3, 4]. The literature supports that effective therapies contain elements of repetition, intense practice, motivation, and task application [5–13]. Enriched environments, patient involvement and empowerment, and functional and purposeful tasks have been shown to increase patient motivation, recovery, and carryover of learned function to the home [3, 5–22]. For example, research performed by Trombly, Wu, and colleagues showed that both normal subjects and stroke survivors reach more efficiently and accurately when functional objects were used as the reach target, i.e., when the reach was more purposeful [3, 17–19]. They proposed that when objects are present (object present) as a goal the person can obtain sensory information regarding the task at hand while if there is no object available (object absent), there is no visual goal information by which to organize movement. Although further research is still needed, these results suggest that these therapeutic approaches can improve functional outcomes for the stroke patient and suggest that robot-assisted therapy may benefit by increasing its task-oriented nature.
Currently, robotic therapy environments are promising tools for stroke rehabilitation. They are capable of administering therapy under minimal supervision, at high intensity, and for long durations. The effectiveness of some of the current robotic therapy systems, such as the MIT-Manus , the GENTLE/s  and the MIME [25, 26], has been tested and typically patients using them have seen faster recovery, decreased impairment, increased accuracy of movement, decreased task completion time, and smoother movements than their counterparts who received traditional therapy [2, 27, 28]. Despite these successes, robot therapy environments often face the same problems that conventional therapy methods face when it comes to carryover of motor gains to real life. Patients who use current robotic therapy environments show inconsistent carryover of the gains made in a therapy session to their home environment. It has been suggested that this may be because the patients are not performing 'real' tasks in the therapy environment so they are not able to map the movement kinematics that they learned in therapy to their daily tasks.
To assist both reaching and/or manipulation movements in the ADLER therapy environment, trajectories must be programmed in to the robotic system. Currently the trajectories that are programmed into most robotic therapy environments are based on 5th or 7th order polynomials derived from the minimum jerk theory of movement assuming zero start and end velocities and accelerations and straight line movements [31, 32]. Developed by Hogan and Flash [31, 37–42] after observing invariant patterns in point-to-point human arm movements, the minimum jerk theory for multi joint arm movements have been shown to work well for point-to-point trajectory generation in many robotic therapy environments [33–36]. However, since we wish to not only support point-to-point movements, but also full functional movements in the ADLER environment, it is necessary for us to analyze natural movements to real life objects and determine if the current models are adequate (Fig. 1b).
In this paper, we used motion analysis tools to investigate functional movements generated during the completion of tasks such as eating and drinking. We compare these functional movements to those predicted by the minimum jerk model since this model is often used for trajectory generation during robot-assisted movements. Specifically, we investigate the motor performance of able-bodied subjects on functional eating and drinking tasks under three conditions; 'object present', 'object absent', and 'object imagined'. We fit the 5th order minimum jerk model to the data and examine the differences seen in the movement under the three conditions. We hypothesized that due to the addition of functional constraints and requirements the minimum jerk trajectory model will fit the 'object absent' condition the best and the 'object present' condition the least. Only, the initial reaching event of the drink and feed tasks are analyzed and presented below. Since the minimum jerk trajectory theory was developed based upon the observations of point-to-point reaching movements. We expected that the reaching events of these tasks to produce trajectories that were most comparable to those predicted by the minimum jerk model. We discuss implications of these findings for modelling functional movements and robot mediated support of these movements.
Drink and Feed Tasks Conditions and Corresponding Events
Reach to cup
Reach to imaginary cup
Touch center of table (approx. 10 inches from edge)
Bring cup to mouth (drink)
Pretend to drink from imaginary cup
Return cup to table
Return imaginary cup to table
Touch center of table again
Return to rest
Return to Rest
Return to Rest
Reach to spoon
Reach to imaginary spoon
Touch ND side of table (approx. 7 inches from edge and 7 inches from midline)
Bring spoon to bowl to scoop pudding
Pretend to scoop pudding from imaginary bowl
Touch center of table (approx 5 inches from edge)
Bring spoon to mouth to eat pudding
Bring imaginary spoon to mouth
Return spoon to table
Return imaginary spoon to table
Touch ND side of table again
Return to Rest
Return to Rest
Return to Rest
The Drink Task (Present, Imagined, and Absent)
The Feed Task (Present, Imagined, and Absent)
The feed task was also performed under all three conditions. This task is used in the analysis since it differs from the drink task in both object orientation and location. The spoon used in this feed task was placed 7 inches from the table edge and 7 inches from the subject's midline on the ND side (Fig. 2b). The feed task was performed in the same three conditions as the drink task.
For motion data collection subjects were instrumented with 12 reflective markers attached over specific bony landmarks using double sided hypoallergenic tape (Fig. 2c). Fifteen Vicon cameras (Vicon Motion Systems Inc.; Lake Forest, CA) recorded the data at 120 Hz by tracking infrared light that was reflected from the markers worn by the subjects. The Vicon 524 motion analysis system provided the three-dimensional coordinates of the markers in space and it was then possible to reconstruct the patients' upper body and their upper extremity movements.
Reconstruction of the Upper Extremities and the Kinematic Model
A bilateral upper extremity model, previously developed by Hingtgen et al  and verified for accuracy [44, 45], was used to reconstruct the motion of the right and left upper extremities from the VICON data set and to determine the Cartesian joint position and orientation. The model consists of five body segments each of which was defined by at least three non-collinear markers; these were the trunk, the right, and left upper arms and the right and left forearm . These five upper body segments as well as the markers used to define them can be seen in Fig. 2c. The joint centers and joint axes were defined though subject specific anthropometric measurements taken when the subject arrived, as well as marker placement. The position of the joint centers was used as the segment's local coordinate system and the trunk segment was defined with reference to the lab coordinate system. For each task, the markers were manually labeled on the Vicon Body Builder (Vicon, lake for CA), events were marked according to velocity profiles, the data was filtered via a Woltring filter with a predicted mean square error of 20, and then the tasks were loaded for reconstruction.
Our trajectory analysis focused on the Cartesian wrist center data. The model defined the wrist joint center as being located halfway between the radial and ulnar markers according to the following equation (Eq. 1):
In Equation 1, is the radial marker and is the ulnar marker.
A custom MATLAB program was used to process and analyze the Cartesian wrist center raw and normalized data corresponding to the desired event(s). Here, we analyze the data for Event 1. Other aspects of the tasks are examined in detailed in Wisneski 2006 . Each reaching event was defined by way of the velocity vector to determine when the subjects started and ended each movement. For example, the reach-to-cup and reach-to-spoon events were defined as beginning at the frame before the initial velocity of the movement and ending at the frame before a change in the velocity vector to indicate the movement of the artifact toward the mouth or bowl.
The Cartesian raw filtered data was used to calculate the following kinematic dependent variables: total displacement (TD), movement time (MT), peak velocity (PV), and movement smoothness (MS). Here, TD is the sum of the raw instantaneous displacements, PV is the maximum velocity value recorded for an event, MT is the total time required to reach the object, and movement smoothness is the number of changes in accelerations within an event.
Normalization of the raw data was performed by subtracting the patient's rest position in Cartesian coordinates from all points along the trajectory, thus all data sets began at (0, 0, 0). The normalized position data were examined for each of the three task conditions. Two key planes of movements (XY and XZ) were analyzed. The XY plane is the horizontal plane of the table and the XZ plane is the vertical plane corresponding to the saggital plane of the torso (Fig. 2). Since subjects moved at their own pace, a 6th order polynomial was used to fit the data for each patient trial and to generate trajectories of the same lengths. The 6th order polynomial was chosen because it was found that it did not compromise or distort the reaching data. The instantaneous tangential velocity was also calculated and plotted for analysis under each condition. Data for the three trials for each subject and all patients in each condition were averaged and resulted in average trajectories for 1–100% of the reach.
The minimum-jerk model was applied next and the resulting curves compared to the average wrist paths generated by the subjects. The context under which the minimum jerk model was calculated was the same as that used to determine point-to-point trajectories in many current robotic therapy environments. Assuming the boundary conditions of zero beginning and ending velocity and acceleration and supplying the initial and final points of the movement in the x, y, and z planes, the 5th order polynomial equations were used to generate predicted trajectories (Eq. 3) :
x(t) = x o + (x o - x f )(15T4 -6T5 - 10T3)
y(t) = y o + (y o - y f )(15T4 -6T5 - 10T3) (Eq. 3)
z(t) = z o + (z o - z f )(15T4 -6T5 - 10T3)
In Eq. 3, x o , y o , and z o are the starting points of the movements (at t = 0) x f , y f , and z f are the final points (at t = t f ). T is scaled as . Using these equations, we calculated model trajectories for each of the average movement conditions ('present', 'imagined', and 'absent') as well as for all of the individual subject movements in both the XY and XZ planes.
To compare the model and actual trajectories, two metrics were used: the difference in area between curves and curvature. The difference between the averaged and minimum jerk model data was quantified by calculating the area between the curves. The area between curves was calculated for each subject's performance in each condition in both the XY and XZ planes. Since the distance between start and end-points vary, the area was normalized by distance. The curvature was quantified and analyzed using the parametric equations 4 and 5. These equations have been used in many other trajectory analyses and are derived from generalized curvature equations [38, 47].
In Eqs. 4 and 5, curvature in the planes are calculated by way of the instantaneous velocities in the , and and the instantaneous accelerations , and . To eliminate any effect due to our polynomial fit procedure, we analyzed the curvature within 5% – 95% of the reach.
Since the average data for each condition was used for much of the analysis, a repeated measure ANOVA was conducted using MINITAB to determine significant differences both between subject trials and across subjects for all of the comparisons. The condition of task performance (i.e. 'object present', 'object imagined', or 'object absent') as well as subject number were used as terms in the ANOVA model. The subject number was also used as a random factor. For each ANOVA, Tukey's test was used to determine significance between each of the conditions and across subjects if necessary. In order to determine if the heterogeneity in the subject population such as differences in age and arm length affected the results, a repeated measure ANCOVA was conducted using these two variables as covariates.
The dependent variables were also analyzed using the repeated measure ANOVA. When required Tukey's test was performed to determine which conditions produced significantly different dependent variables of movement. We anticipated that the 'object present' condition would show dependent variables reflecting more organized movements, i.e., smooth reaches and shorter times [17–19]. We also expected higher velocities and longer displacements for the object present conditions.
Averaged Movement Dependent Variables for each condition.
350 +/- .06
400 +/- .04
320 +/- .05
I > P & A
.94 +/- .09
.96 +/- .1
893.5 +/- 14
754.8 +/- 11
781.6 +/- 8.9
P > I & A
MS (+/- uts)
3 +/- .25
3 +/- .25
3 +/- .5
250 +/- .02
230 +/- .01
P > I & A
.78 +/- .1
.82 +/- .11
.77 +/- .08
752 +/- 9
788 +/- 8.8
761 +/- 9.5
I > P & A
MS (+/- uts)
2 +/- .2
2 +/- .4
2 +/- .25
The data for the feed task shows that again there is no statistically significant difference for total displacement, movement time, or movement smoothness between any of the three conditions. In the case of the peak velocity, the object imagined condition shows significantly greater peak velocity than the object present and absent conditions do which are not significantly different from each other. It is possible that we do not see the same pattern in peak velocity as for the drink task due to the fact that all three conditions of this task were much more similar to each other and resembled a point-to-point reach more closely than the drink task did. This may have caused the three conditions to be performed more similarly in dependent variables.
The Drink Task
It is clear from Figure 3 (left) that the model in the XY plane does fit the 'object absent' (point-to-point) condition the best. The 'object present' condition produces the trajectory that shows the most deviations from the minimum jerk model data.
In contrast, the trajectories in the XZ plane do not fit the model data in any of the three conditions. All conditions produce a movement with a similar curvature pattern that shows a large displacement in the Z (vertical) direction. The curvature seen in this plane is thought to be a result of the subjects reaching in an 'up-and-over' fashion to work around the table constraint due to the starting location and position of their hand. Since the subjects begin the tasks with their palms face down on the table it may have been natural to lift the hand as the movement occurs to be sure the hand clears the table as the goal is approached.
The Feed Task
The XY data in figure 4 (left) shows that the trajectories for the reach-to-spoon task in all three conditions are not statistically significantly different from each other (p = 0.405), which is not what was seen in the drink task where the 'object present' condition produced movements with greater curved deviations. The XZ data in figure 4 (right) shows that there is a similar curvature pattern and deviation in the positive Z direction to that seen in the drink task. This again is thought to be due to the table constraint.
Velocity for feed and drink tasks
As can be seen in figure 5, the velocities for all of the minimum jerk model data are symmetric bell shaped profiles with 0 beginning and ending velocity as expected. A salient feature across both tasks is that unlike the model data, the actual data does not show subjects ending the reach at zero velocity.
The velocity profiles for the reach-to-spoon event reach a peak of a lesser magnitude than those of the reach-to-cup event (p < 0.001). This is expected since the distance travelled to the cup was greater than that travelled to the spoon (Table 2). The 'object present' condition of the drink task produced the greatest peak velocity.
Another point of interest between tasks is that the velocity profiles for the reach-to-spoon task are more symmetric (peak at 50.35 +/- 8%) and closer to the minimum jerk prediction than the velocity profiles for the Reach-to-cup task (peak at 37.75 +/- 1.5%).
Differences between Model and Reach-to-Cup and Reach-to-Spoon
In order to quantify some of the differences seen between averaged data and what the model predicts, two metrics were looked at; the area between curves and the curvature of the paths.
Initially it can be seen that the areas in the XZ plane for both the drink and feed tasks are more than double the areas in the XY plane (XY average = 1121 mm2, XZ average = 2922 mm2) (Fig. 6). These results show that movements in the XZ plane produced more curvature deviations than those in the XY plane.
In this figure, the first feature to note is that for all movements the maximal curvature is at the beginning and end of the movements. Another interesting feature can be noted at the curvature minima. In the XZ plane, the average minimal curvatures deviate more from 0 than in the XY plane (XZ average: 0.0031/mm > XY average: 0.0007 (p < .001). This shows that at the minimal curvature, the movement in the XZ plane shows the greatest deviations from the minimum jerk trajectory, which is 0, in all three conditions. This will be important information in the development of a functional trajectory model.
The XY plane data (Fig. 6) for the drink task shows that the object present condition produces significantly greater curvature than the object absent and imagined conditions (p < 0.05), which are not significantly different from each other (p = 0.087). This shows that the addition of a functional object, in this case a cup, creates deviations from the minimum jerk trajectory that are not otherwise seen. The object absent condition produces trajectories that are the most repeatable in their resemblance to the minimum jerk model data as can be seen by the small standard deviation.
The XZ plane data for the drink task reveals a similar pattern. Again the object present condition produced a trajectory with the greatest deviation. The object imagined condition produced a trajectory with greater deviation than the object absent condition in the XZ plane. This may have been occurred because the subject was imagining a handle of a cup that was raised from the table top, thus requiring a different approach in the vertical direction than for the object absent condition.
Looking at the feed task in the XY plane it can be seen that there is no statistical difference between any of the three conditions. This shows that the orientation required for grasping and manipulating the spoon in this location required a wrist trajectory similar to that required to point to the same location. All three feed conditions in the XY and XZ planes show a significantly lesser area than those for the drink task. This indicates that the trajectories generated in the feed task follow more closely to the minimum jerk model than those for the drink task. This highlights the importance of object affordance and placement. The differences seen between the drink and feed task indicate that a functional model must accommodate a wide range of object affordances in order to be adequate to implement in the robotic therapy environment.
Finally, when a repeated measure ANOVA was conducted it was found that there were not interactions across subjects or trials within each condition. The results for the repeated measures ANCOVA showed that the age and arm length of the subjects did not significantly affect the wrists paths. Thus, the averaged data is used in the subsequent analysis.
Through the data presented here we have highlighted concerns that must be addressed when modeling functional movements. We have shown that as object affordance changes there are significant differences in the kinematics, specifically in the curvature of movements performed. These findings are important to consider when implementing trajectories in robotic therapy environments for stroke rehabilitation. Our results agree with previous research, which has shown that object affordance and functional goal performance can influence therapy outcomes [17–19]. These task-dependent, functional improvements are important when planning therapy options for stroke survivors because of the influence that functional task practice may have on brain plasticity [48–53]. Many previous studies have shown that it is important to support functional activities in therapy environments in order to achieve optimal recovery [50–53].
The data we have presented indicates that in order to support these functional tasks in our robotic therapy environment it is necessary to accommodate the curvature deviations from the minimum jerk model seen in these trajectories. The major differences that we have highlighted include trajectory dependence on: object presence, object orientation, and the plane of movement.
We have shown that when subjects reach to a point in space or an imaginary object, their trajectories adhere more closely to the predicted minimum jerk model than when there is an actual object present (Figs. 3 and 4). Studies have shown that when subjects are performing functional reaching to real-life objects the orientation of the hand and the grasp aperture is adjusted to accommodate for object orientation, shape, and size [54–57]. We looked at both the XY and XZ data for reaches to a cup and a spoon. In the XY plane, our data show that when the subjects reached to the cup, versus a point in space, their trajectories became more curved (Fig. 3). This is thought to be due to the hand orientation for grasping and stabilization requirements of the functional task. Grasping and orientation has been a topic of much previous research [54–63]. It has been shown that the orientation of the hand when approaching an object depends on many variables including object shape, size, orientation, location, and properties (such as weight and friction characteristics) [55, 58–63].
Comparatively, this did not apply to reaches to a spoon. In the case of the spoon, the trajectories in the XY plane were not significantly different between conditions. This is thought to be because the location of the spoon on the table and the hand orientation required to grasp the spoon were similar to the requirements of the point-to-point version of the task. Thus all three conditions resulted in more similar movements than seen in the drink task where when the subjects were required grasp a cup, their trajectory became more curved.
The XZ trajectories show similar patterns across the drink and feed tasks (Figs. 3 and 4). Vertical (Z-direction) deviations can be seen for these reaches to both objects. These deviations are thought to be due to the avoidance of the table constraint. The fact that the same pattern is seen in the XZ plane for two tasks requiring different hand orientation and positioning indicates that this may be an important feature of movement to be considered for the functional model. The differences in the XY plane data indicate trajectory dependence on object location and orientation. From this analysis it can be concluded that it will be important for the model to both capture patterns of movements that are invariant across tasks as well as react differently to various object and task specific requirements.
The data from the velocity profiles and from the dependent variables support the Cartesian wrist trajectory findings. The 'object present' condition of the drink task shows the greatest peak velocity (Table 2 and Fig. 5). The fact that the peak velocity is greatest when there is a functional object present agrees with the data collected by Trombly, Wu, and colleagues which shows that object affordance leads to movements with improved dependent variables including higher peak velocities [17–19]. This does not apply in the case of the feed task however. Just as in the Cartesian data we see a closer resemblance to the point-to-point version of the task. This is thought to be due to the object affordance. The spoon was laying flat on the table and required the subjects to perform a movement more closely resembling a point-to-point reach. The cup required the subjects to reach out of the plane of the table to the handle, thus deviating from planar point-to-point movements more. This again supports the need for the model to account for various task specific requirements rather than approaching all functional tasks in the same way.
Finally the curvature analysis also agrees with these findings as we see that the drink task produces greater area between curves than the feed task (Fig. 6). In addition, when looking at the drink task, that the XZ plane shows greater minimal curvature than the XY plane (Fig. 7). This brings an important point for modeling considerations to light. The functional model that is developed must account for this increased curvature seen in the XZ plane, while providing significantly less curvature in the XY plane.
This analysis has helped us to see that trajectory dependence on object presence, orientation, and plane of movement, will prove to be critical in developing a functional model. Supporting highly functional activities via a robot-assisted environment will require a trajectory model that considers these object affordances and the influence of the plane of movement on the trajectory paths.
Sources of Error and Other Considerations
The data we have presented here comes from a small sample (8 subjects) the question of how this sample will generalize to the population must be considered. However, we do see a high level of repeatability between subjects indicating that the patterns we observe are characteristic of natural movements. We will have to investigate more tasks and more task types to determine how various objects, object placements, and goals affect trajectories.
The constraints that we put on the tasks to control the data set may not account for all natural movement settings. We required the subjects' hands to start and end each task in a prescribed rest position. This positioning of the hand may have affected the reach trajectory. Other rest positions should be considered.
Variability between trials and subjects could also be a source of error for our data set. Objects may have been moved slightly between trials. And the point-to-point location prescribed did not have a visual cue so subject may have reached to different locations for each trial.
Finally, since our goal is to implement this trajectory model on a stroke therapy system, we must consider how the trajectories may need to be adjusted for stroke survivors. We expect to see movements with lower peak velocities, increased total displacements, and decreased smoothness. We expect that the velocity profiles will have multiple peaks to account for adjustments made in movement direction. These and other factors must be studied in order to make this mode appropriate for stroke survivors.
The data presented in this paper confirms that a new approach is necessary when implementing functional tasks in the ADLER therapy environment. From this data we have learned that we not only have to be concerned with the transport component of the reach and moving the patients hands to the proper location, but also with the orientation component of the reach and positioning their hands properly to grasp the object. Since the orientation component seems to be captured in the increased curvature of the trajectory this will be the focus of the model we are creating.
In the drink and feed tasks from the previous analysis, only two objects were analyzed; the cup and the spoon. These objects were of different shape, size, orientation, and location on the activity table. The fact that all of these variables were varied at the same time, does not allow for individual causes of path shape difference to be determined. A future experiment that specifically examines the effect on the wrist path of individually varying each of these variables in order to determine which variables cause what type of curvature deviations would be very valuable. Many more object types should be examined as well as more object locations. With this information it would be possible to update the model so that inputs could include object location, orientation, size, and shape and result in more appropriate path generation.
In the future, we will explore the patterns in curvature and velocity that emerge between sets of like movements within tasks for complete tasks. We will look at the other paradigms for implementing the minimum jerk theory of movement including the via-point application to help in the development of a new model for implementation in ADLER. We will also investigate the differences seen between stroke patients' and normal, healthy subjects' movements to determine what adaptations to the model are necessary. We will then implement this model on the ADLER environment.
By developing a model that will allow the execution of more natural movements in their rehabilitation we hope to create an environment that affords patients reliable and repeatable practice of activities of daily living. When patients are trained with functional task specific movements using natural trajectory patterns we hope to elicit brain plasticity to encode for these natural movements. Through their practice of daily living exercises we hope to see gains made in their movement kinematics and increases in their functional ability. We also hope to increase patients' confidence in executing real-life tasks with their impaired arm so that carryover is increased.
We would like to acknowledge the following supporting grants; Medical College of Wisconsin (MCW), Advancing a Healthier Wisconsin Grant Program #5520015, MCW Research Affairs Committee Grant #3303017, and NIH R24 Rehabilitation Institute of Chicago #2203792. We thank John Anderson for all of the work he has done leading to the development of the ADLER environment and Dominic Nathan, and Michael Poellman for their work with data collection and processing. We thank Brooke Hingtgen, and Jason Long for assisting us in the Orthopaedic Rehabilitation Engineering Lab (OREC) Human Motion Lab. Finally, we thank the students in Rehabilitation Robotics Research and Design Lab, which is supported by the Medical College of Wisconsin, the Clement Zablocki VA, and Marquette University.
- Volpe BT, Ferraro M, Lynch D, Christos P, Krol J, Trudell C, Krebs HI, Hogan N: Robotics and other devices in the treatment of patients recovering from stroke. Current Neurology & Neuroscience Reports 2002,5(6):465-70.View ArticleGoogle Scholar
- Heart Disease and Stroke Statistics – 2005 Update Dallas, TX American Heart Association; 2005.Google Scholar
- Trombly C, Hui-ing MA: A synthesis of the effects of occupational therapy for persons with stroke, Part I: Restoration of roles, tasks, and activities. Am J Occup Ther 2002,56(3):250-259.View ArticlePubMedGoogle Scholar
- Fisher BE, Sullivan KJ: Activity-Dependent factors affecting poststroke functional outcomes. Top Stroke Rehabil 2001,8(3):31-44.View ArticlePubMedGoogle Scholar
- Karni A, Meyer G, Rey-Hipolito C, Jezzard P, Adams MM, Turner R, Ungerleider LG: The acquisition of skilled motor performance: Fast and slow experience-driven changes in primary motor cortex. Proceedings-National Academy of Sciences USA 1998,95(3):861-868.View ArticleGoogle Scholar
- Zohary E, Celebrini S, Britten KH, Newsome WT: Neuronal plasticity that underlies improvement in perceptual performance. Science 1994, 5151: 2189.Google Scholar
- Karni A, Meyer G, Jezzard P, Adams MM, Turner R, Ungerleider LG: Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature 1995,377(6545):155-158.View ArticlePubMedGoogle Scholar
- Classen J, Liepert J, Wise S, Hallett M, Cohen LG: Rapid plasticity of human cortical movement representation induced by practice. Journal of Neurophysiology 1998,79(2):1117-1123.PubMedGoogle Scholar
- Rioult-Pedotti MS, Friedman D, Hess G, Donoghuel JP: Strengthening of horizontal cortical connections following skill learning. Nature Neuroscience 1998,1(3):230-234.View ArticlePubMedGoogle Scholar
- Maclean N, Pound P, Wolfe C, Rudd A: Qualitative analysis of stroke patients motivation for rehabilitation. British Medical Journal 2000,321(7268):1051-1054.PubMed CentralView ArticlePubMedGoogle Scholar
- Holmqvish LW, Koch L: Environmental factors in stroke rehabilitation, Being in hospital itself demotivates patients. British Medical Journal 2001, 322: 1501-02.View ArticleGoogle Scholar
- Will B, Galani R, Kelche C, Rosenzweig MR: Recovery from brain injury in animals: relative efficacy of environmental enrichment, physical exercise or formal training (1999–2002). Progress in Neurobioloby 2004,72(3):167-182.View ArticleGoogle Scholar
- Nudo RJ: Functional and structural plasticity in motor cortex: implications for stroke recovery. Physical Medicine & Rehabilitation Clinics of North America 2003,14(1):57-76.View ArticleGoogle Scholar
- Wood SR, Murillo N, Bach-y-Rita P, Leder RS, Marks JT, Page SJ: Motivating, game-based stroke rehabilitation: a brief report. Topics of Stroke Rehabilitation 2003,10(2):134-40.View ArticleGoogle Scholar
- Bach-y-Rita P: Theoretical and practical considerations in the restoration of function after stroke. J Top Stroke Rehabil 2001,8(3):1-15.View ArticleGoogle Scholar
- Aycock DM, Blanton S, Clark PC, Wolf SL: What is constraint-induced therapy? Rehabilitation Nursing 2004,29(4):114-115.View ArticlePubMedGoogle Scholar
- Trombly C: Occupational Therapy of Physical Dysfunction. Baltimore (MD): Williams & Wilkins; 1995.Google Scholar
- Wu C, Trombly CA, Lin K, Ticke-Degnen L: A kinematic study of contextual effects on reaching performance in persons with and without stroke: Influences of object availability. Arch Phys Med Rehabil 2000,81(1):95-101.View ArticlePubMedGoogle Scholar
- Wu C, Trombly CA, Lin K, Ticke-Degnen L: Effects of object affordances on reaching performance in persons with and without cerebrovascular accident. Am J Occup Ther 1998,52(6):447-56.View ArticlePubMedGoogle Scholar
- Wittenberg GF, Chen R, Ishii K, Bushara KO, Taub E, Gerber LH, Hallet M, Cohen LG: Constraint-induced therapy in stroke: magnetic-stimulation motor maps and cerebral activation. Neurorehabilitation and Neural Repair 2003,17(1):48-57.View ArticlePubMedGoogle Scholar
- Liepert J, Bauder H, Miltner WHR, Taub E, Weiller C: Treatment-induced cortical reorganization after stroke in humans. Stroke 2002, 31: 1210-1216.View ArticleGoogle Scholar
- Thielman GT, Dean CM, Gentile AM: Rehabilitation of reaching after stroke: task related training versus progressive resistive exercise. Archives of Physical Medicine and Rehabilitation 2004, 85: 1613-1618.View ArticlePubMedGoogle Scholar
- Krebs HI, Volpe BT, Hogan N: Robot-aided neurorehabilitation: from evidence-based to science-based rehabilitation. Top Stroke Rehabil 2002,8(4):54-70.View ArticlePubMedGoogle Scholar
- Loureiro R, Harwin W, Amirabdollahian F: A Gentle/s Approach to Robot Assisted Neuro-Rehabilitation. In Advances in Rehabilitation Robotics: Human Friendly Technologies on Movement Assistance and Restoration for People with Disabilities. Lecture Notes in Control and Information Sciences. Volume 306. Edited by: Bien Z, Stefanov D. Germany:Springer; 2004:347-363.View ArticleGoogle Scholar
- Burgar CG, Lum PS, Shor PC, Van der Loos HFM: Development of robots for rehabilitation therapy: the Palo Alto VA/Stanford experience. J Rehabil Res Dev 2000,37(6):663-674.PubMedGoogle Scholar
- Lum P, Reinkensmeyer D, Mahoney R, Rymer WZ, Burgar C: Robotic Devices for movement therapy after stroke: Current status and challenges to clinical acceptance. Top Stroke Rehabil 2002,8(4):40-53.View ArticlePubMedGoogle Scholar
- Taub E, Lum PS, Hardin P, Mark V, Uswatte G: AutoCITE, Automated delivery of CI therapy with reduced effort by therapists. Stroke 2005, 36: 1301.View ArticlePubMedGoogle Scholar
- Fasoli SE, Krebs HI, Hughes R, Stein J, Hogan N: Functionally-based rehabilitation: Benefits or Buzzwrod? In Proceedings of International Conference on Rehabilitation Robotics (ICORR). Chicago IL; 2005:223-26. June 28–July 1 2005Google Scholar
- Fugl-Meyer AR, Jaasko L, Leyman I: The post-stroke hemiplegic patient. A method for evaluation of physical performance. Scandinavian Journal of Rehabilitation Medicine 1975, 7: 13-31.PubMedGoogle Scholar
- Johnson MJ, Wisneski KJ, Anderson J, Nathan D, Smith R: Development of ADLER: The Activities of Daily Living Exercise Robot. In IEEE-EMBS Biomedical Robotics (BioRob 2006). Pisa, Italy; 2006:881-886.Google Scholar
- Flash T, Hogan N: The coordination of arm movements: An experimentally confirmed mathematical model. The Journal of Neuroscience 1985, 5: 1688-1703.PubMedGoogle Scholar
- Amirabdollahian F, Loureiro R, Harwin W: Minimum Jerk Tajectory Control for Rehabilitation and Haptic Applications. In The Humand Interface Laboratory Department of Cybernetics. The University of Reading;Google Scholar
- Krebs HI, Palazzolo JJ, Dipietro L, Ferraro M, Krol J, Rannekleiv K, Volpe BT, Hogan N: Rehabilitation robotics: Performance-based progressive robot-assisted therapy. Autonomous Robots 2003, 15: 7-20.View ArticleGoogle Scholar
- Reinkensmeyer DJ, Takahashi CD, Timoszyk WK, Reinkensmeyer AN, Kahn LE: Design of robot assistance for arm movement therapy following stroke. Advanced Robotics 2001,14(7):625-637.View ArticleGoogle Scholar
- Loureiro R, Amirabdollahian F, Topping M, Driessen B, Harwin W: Upper limb robot mediated stroke therapy-GENTLE/s approach. Autonomous Robots 2003,15(1):35-51.View ArticleGoogle Scholar
- Patton JL, Kovic M, Mussa-Ivaldi FA: Custom-designed haptic training for restoring reaching ability to individuals with stroke. Journal of Rehabilitation Research and Development 2006, in press.Google Scholar
- Hogan N: An organizing principle for a class of voluntary movements. Journal of Neuroscience 1984, 4: 2745-2754.PubMedGoogle Scholar
- Hogan N, Flash T: Moving gracefully: quantitative theories of motor coordination. TINS 1987,10(4):170-174.Google Scholar
- Abend W, Bizzi E, Morasso P: Human arm trajectory formation. Brain 1982, 105: 331-348.View ArticlePubMedGoogle Scholar
- Atkeson CG, Hollerbach JM: Kinematic features of unrestrained vertical arm movements. Journal of Neuroscience 1985,5(9):2318-2330.PubMedGoogle Scholar
- Morasso P: Spatial control of arm movements. Journal of Experimental Brain Research 1981, 42: 223-227.PubMedGoogle Scholar
- Uno Y, Kawato M, Suzuki T: Formation and control of optimal control trajectories in human multijoint arm movements: Minimum torque change model. Biological Cybernetics 1989, 61: 89-101.View ArticlePubMedGoogle Scholar
- Hingtgen BA, McGuire JR, Wang M, Harris GF: Design and validation of an upper extremity kinematic model for application in stroke rehabilitation. Proceedings IEEE/Engineering and Med Biol Society 2003, 25: 200.Google Scholar
- Bachschmidt RA, Harris GF, Simoneau GG: Walker assisted gait in rehabilitation: A study of biomechanics and instrumentation. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2001, 9: 96-105.View ArticlePubMedGoogle Scholar
- Baker KM, Wang M, Cao K, Lipsey L, Long JT, Reiners K, Johnson C, Olson W, Hassani S, Ackman JD, Schwab JP, Harris GF: Biomechanical system for the evaluation of walker-assisted gait in children: Design and preliminary application. In IEEE Engineering in Medicine and Biology Society. Cancun, Mexico; September 25 2003Google Scholar
- Wisneski K: Development of a Model for Functional Upper Extremity Trajectory Generation and Implementation on the Activities of Daily Living Exercise Robot (ADLER). In Department of Biomedical Engineering. Masters Thesis, Marquette University; 2006.Google Scholar
- Amirabdollahian F: An investigation of roboti-mediated therapies and therapy effects on the recovery of upper limb post stroke. University of Reading, Department of Cybernetics; 2003.Google Scholar
- Bach-y-Rita P: Late post-acute neurologic rehabilitation: neuroscience, engineering and clinical programs. Arch Phys Med Rehab 2003, 84: 1100-1108.View ArticleGoogle Scholar
- Bach-y-Rita P: Volume transmission and brain plasticity. Evolution and Cognition 2002, 8: 115-122.Google Scholar
- Wittenberg GF, Chen R, Ishii RK, Bushara KO, Taub E, Gerber LH, Hallett M, Cohen LG: Constraint-induced therapy in stroke: magnetic-stimulation motor maps and cerebral activation. Neurorehabilitation and Neural Repair 2003,17(1):48-57.View ArticlePubMedGoogle Scholar
- Liepert J, Bauder H, Miltner WHR, Taub E, Weiller C: Treatment-induced cortical reorganization after stroke in humans. Stroke 2002, 31: 1210-1216.View ArticleGoogle Scholar
- Taub E, Uswatte G, Pidikiti R: Constraint-induced movement therapy: a new family of techniques with broad application to physical rehabilitation – a clinical review. J Rehabil Res Dev 1999,36(3):1-18.Google Scholar
- Page SJ, Sisto S, Levine P, McGrath RE: Efficacy of modified constraint-induced movement therapy in chronic stroke: a single-blinded randomized controlled trial. Arch Phys Med Rehabil 2004, 85: 14-8.View ArticlePubMedGoogle Scholar
- Zackowski KM, Thach WT, Bastian AJ: Cerebellar subjects show impaired coupling of reach and grasp movements. Experimental Brain Research 2002, 146: 511-522.View ArticlePubMedGoogle Scholar
- Timmann D, Stelmach GE, Bloedel JR: Grasping component alterations and limb transport. Exp Brain Res 1996, 108: 486-492.View ArticlePubMedGoogle Scholar
- Wing AM, Turton A, Fraser C: Grasp size and accuracy of approach in reaching. J Mot Behav 1986, 18: 245-260.View ArticlePubMedGoogle Scholar
- Gentilucci M: Object motor representation and reaching-grasping control. Neuropsychologia 2002, 40: 1139-1153.View ArticlePubMedGoogle Scholar
- Berthier NE, Clifton RK, Gullipalli V, McCall D, Robin D: Visual information and object size in the control of reaching. Journal of Motor Behavior 1996,28(187):197.Google Scholar
- Fikes TG, Klatzky RL, Lederman SJ: Effects of object texture on precontact movement time in human prehension. Journal of Motor Behavior 1994, 26: 325-223.View ArticlePubMedGoogle Scholar
- Jakobson LS, Goodal MA: Factors affecting higher-order movement planning: A kinematic analysis of human prehension. Experimental Brain Research 1991, 86: 199-208.View ArticlePubMedGoogle Scholar
- Smeets JB, Brenner E: A new view on grasping. Motor Control 1999, 3: 237-271.PubMedGoogle Scholar
- Gentilucci M, Castiello U, Corradini ML, Scarpa , Umilta MC, Rizzolatti G: Influence of different types of grasping on the transport component of prehension movements. Neuropsychologia 1991,29(5):361-378.View ArticlePubMedGoogle Scholar
- Gentilucci M, Daprati E, Gangitano M, Saetti MC, Toni I: On orientating the hand to reach and grasp an object. Neuroreport 1996, 7: 589-592.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.